Michiko Nakano
Michiko M. Nakano
Research Associate Professor
Department of Environmental and Biomolecular Systems
Oregon Health & Science University
20000 NW Walker Road
Beaverton, OR 97006-8921
E-mail: mnakano@ebs.ogi.edu
Phone: 503-748-4078
Fax: 503-748-1464
Alt Phone: Lab: 503-748-1665
Education
Ph. D., Cell Biology, University of Tokyo, 1976
Biography
Mitsubishi-Kasei Institute of Life Science, Postdoctoral Fellow 1977-78
Meiji College of Pharmacy, Tokyo, Assistant Professor (1978-82), Associate Professor (1982-87)
Oklahoma State University, Research Associate, 1987-88
Louisiana State University Medical Center at Shreveport, Research Associate (1988-95), Research Assistant Professor (1995-98)
OGI School of Science and Engineering, Research Assistant Professor, 1998-2000, Research Associate Professor, 2000-present
Research Interests
Anaerobiosis of Bacillus subtilis; oxygen-controlled gene regulation; two-component signal transduction system; transcriptional activation; nitrate/nitrite reductases; flavohemoglobin; anaerobic electron transport; nitric oxide signaling.
Research Project(s)
Anaerobiosis of Bacillus subtilis
Flavohemoglobin (Hmp)
ResD-ResE Two-Component Signal Transduction System
Selected Publications
Moore, C. M., M.M. Nakano, T. Wang, R. W. Ye, and J. D. Helmann. 2004. Response of Bacillus subtilis to nitric oxide and the nitrosating agent sodium nitroprusside. J. Bacteriol. 186:4655-4604.
Hartig, E., H. Geng, A. Hartmann, A. Hubacek, R. Munch, D. Jahn, R. W. Ye, and M. M. Nakano. 2004. Bacillus subtilis ResD induces expression of potential regulatory genes yclJK upon oxygen limitation. J. Bacteriol. 186:6477-6484.
Baruah, A., B. Lindsey, Y. Zhu, and M. M. Nakano. 2004. Mutational analysis of the signal-sensing domain of ResE histidine kinase from Bacillus subtilis. J. Bacteriol. 186:1694-1704.
Geng, H., S. Nakano, and M. M. Nakano. 2004. Transcriptional activation by Bacillus subtilis ResD: Tandem binding to target elements and phosphorylation-dependent and -independent transcriptional activation. J. Bacteriol. 186:2028-2037.
Sawers, G., and M. M. Nakano. 2004. Redox(oxygen)-sensing regulation of facultative anaerobes, pp. 67-86. In: Strict and Facultative Anaerobes: Medical and Environmental Aspects (Nakano, M. M., and P. Zuber, eds.), Horizon Scientific Press, Wymondham, UK.
Nakano, M. M., P. Zuber, and A. L. Sonenshein. 2004. Toxin gene regulation in Clostridium, pp. 199-209. In: Strict and Facultative Anaerobes: Medical and Environmental Aspects (Nakano, M. M., and P. Zuber, eds.), Horizon Scientific Press, Wymondham, UK.
Nakano, S., M. M. Nakano, Y. Zhang, M. Leelakriangsak, and P. Zuber. 2003. A regulatory protein that interferes with activator-stimulated transcription in bacteria. Proc. Natl. Acad. Sci. USA 100:4233-4238.
Nakano, M. M. and P. Zuber. 2002. Anaerobiosis, pp. 393-404, in Bacillus subtilis and Its Closest Relatives (Sonenshein, A. L., J. A. Hoch, and R. Losick, eds.). American Society for Microbiology, Washington, DC.
Nakano, M. M. 2002. Induction of ResDE-dependent gene expression in Bacillus subtilis in response to nitric oxide and nitrosative stress. J. Bacteriol. 184:1783-1787.
Nakano, S., G. Zheng, M. M. Nakano, and P. Zuber. 2002. Multiple pathways of Spx (YjbD) proteolysis in Bacillus subtilis. J. Bacteriol. 184:3664-3670.
Nakano, M. M., S. Nakano, and P. Zuber. 2002. Spx (YjbD), a negative effector of competence in Bacillus subtilis, enhances ClpC-MecA-ComK interaction. Mol. Microbiol. 44:1341-1350.
Galperin, M. Y., T. A. Gaidenko, A. Y. Mulkidjanian, M. Nakano, and C. W. Price. 2001. MHYT, a new integral membrane sensor domain. FEMS Microbiol. Lett. 205: 17-23.
Nakano, M. M. F. Hajarizadeh, Y. Zhu, and P. Zuber. 2001. Loss-of-function mutations in yjbD result in clpX- and clpP-independent competence development of Bacillus subtilis. Mol. Microbiol. 42: 383-394.
M.M. Nakano and Y. Zhu, Involvement of the ResE Phosphatase Activity in Down-Regulation of ResD-Controlled Genes in Bacillus subtilis During Aerobic Growth. J. Bacteriol. 2001, 183, 1938-1944.
